Category Archives: Number

The Use of Surgical Lasers in the Treatment of Oral Leukoplakia

Bögözi B1, Bocskay I2

1 Department of Oral and Maxillofacial Surgery, Faculty of Dental Medicine, University of Medicine and Pharmacy, Tîrgu Mureş, Romania
2 Department of Odontology and Parodontology, Faculty of Dental Medicine, University of Medicine and Pharmacy, Tîrgu Mureş, Romania

Introduction: Surgical lasers are more and more often used in our days in medicine, including oro-maxillo-facial surgery. Because of their many advantages the application of surgical lasers became the elective method in the surgical treatment of oral leukoplakia – according to the recomandation of the WHO.
Material and method: In this paper two clinical cases are presented showing the methods and advantages of using surgical lasers in the treatment of oral leukoplakia. For the surgery a 15 W maximum power Biolitec diode laser was used.
Results and conclusions: The ideal haemostasis during surgery; the shortened intervention (and through this the reduction of physical an psychological stress of the patient); minimal scar tissue formation; the unnecessity to cover sometimes important postoperative defects, reduced risk of dissemination of modified cells are such advantages of the use of surgical lasers, that eliminate the difficulties of classic surgical techniques and lead to spreading of a new concept in the surgical treatment of premalignant lesions of the oral mucosa.

Keywords: , ,
Full text: PDF

Clindamycin — an Option for Antibiotic Prophylaxis In Arthroplasty

Bod P, Kurtus I, Incze S, Moldovan Rodica, Vâlcu A, Nagy Ö

Orthopaedics and Traumatology Clinic, Emergency County Hospital, Tîrgu Mureş, România

Introduction: Generally joint arthroplasties, but especially hip arthroplasties, are perhaps the most widespread types of orthopedic surgeries. These types of interventions are special because of the possibility of bacterial complications occurring due to the implant.
Material and method: Between 2008–2009 a total of 48 patients were administered Clindamycin 600 mg iv, as antibiotic prophylaxis, specifying that administration was performed according to the international protocol. During follow-up we monitored the efficiency of perioperative antibiotic prophylaxis in patients by determining the C-reactive protein and the erythrocyte sedimentation rate.
Results: The patients’ postoperative evolution at the site of the surgical wound presented no complications, except two cases of wound dehiscence caused by superficial hematoma which were subsequently solved with a secondary suture.
Conclusions: Clindamycin is used for preventive purposes especially in those protocols where beta-lactam allergy occurs. Clindamycin can also be used instead of cephalosporins in perioperative antibiotic prophylaxis. Our results are in accordance with those met in the speciality literature.

Keywords: , , ,
Full text: PDF

FLT3 Internal Tandem Duplication and D835 Mutations in Acute Myeloid Leukemia

Bănescu Claudia1, Dobreanu Minodora2, Duicu Carmen3, Benedek I4, Macarie I5, Köpeczi Judit4

1 Department of Genetics, University of Medicine and Pharmacy, Tîrgu Mureş, Romania
2 Department of Clinical Biochemistry, University of Medicine and Pharmacy, Tîrgu Mureş, Romania
3 Pediatric Clinic, University of Medicine and Pharmacy, Tîrgu Mureş, Romania
4 Hematology Clinic 2, University of Medicine and Pharmacy, Tîrgu Mureş, Romania
5 Hematology Clinic 1, University of Medicine and Pharmacy, Tîrgu Mureş, Romania

Introduction: FLT3 is a member of receptor tyrosine kinases expressed in leukemic cells. Internal tandem duplications (ITDs) and D835 mutations in FLT3 tyrosine kinase receptor have been shown to confer a bad prognosis in acute myeloid leukemia (AML). The aim of the present study was to determine the incidence of both ITD and D835 mutations in the FLT3 gene, in patients with AML from Tg-Mures, Romania.
Materials and methods: DNA was obtained from peripheral blood samples. ITDs were investigated by polymerase chain reaction (PCR). D835 mutations were analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), with the digestion of restriction endonuclease EcoR V. The amplified and restricted products were finally electrophoresed on agarose gel stained with ethidium bromide.
Results: Alterations in the FLT3 gene were detected in 8 patients out of the 23 cases analyzed. These aberrations included ITD in 4 cases, D835 mutations in 2 cases and both types of alteration (ITD + D835) in 2 patients.
Conclusion: In this study we demonstrated that FLT3 mutations are frequent molecular abnormalities in AML patients with an incidence of 34.8%. Although our data do not support its value as a prognostic factor in AML patients because of the small cohort, further investigation is required.

Keywords: , ,
Full text: PDF

Extracranial Jugular Venous Insufficiency in Multiple Sclerosis Patients Treated with Interferon Beta

Bălaşa Rodica, Bajkó Z, Stan Camelia

First Neurological Department, University of Medicine and Pharmacy, Tîrgu Mureş, Romania

Background: The term „vascular immunology” was created when recent studies have suggested that topographic perivenous pattern of demyelinated MS plaques may be caused by venous congestion. This condition termed as „chronic cerebrospinal venous insufficiency” has raised important issues. Our objective was to investigate the haemodinamics of the internal jugular vein (IJV) using extracranial Color-Doppler (ECD) sonography in MS patients treated with IFN-β.
Methods: 140 patients with MS (mean age: 41.1±9.2, mean EDSS: 2.73±1,96, 68.6 % RRMS and 31.4 % SPMS, mean relapses in the past 12 months: 0.43±0.61 with at least 18 months of IFN-β treatment as unique DMT, underwent ECD with detection of four parameters: A – reflux present in IJV; B – evidence of proximal IJV stenosis; C – flow not Doppler detectable in IJV; D – negative difference in the cross sectional area in IJV supine/sitting postures. We studied which criteria correlate significantly with EDSS, number of relapses, form of MS and time to initiation of therapy.
Results: Thirty patients (21.8 %) had at least 2 unilateral parameters present on IJV. This patients had significantly more frequent SPMS (p=0.02), higher EDSS (p=0.04) and started later IFN-β therapy (p=0.03). Taken separately, the number of parameters C+D correlates significantly with EDSS (p=0.04) and form of MS (p=0.01).
Conclusions: ECDS is non-invasive, repeatable, cost-effective and permits to investigate the cerebral venous outflow. The frequency of ECDS criteria in our patient group is significantly lower compared with the results published by Zamboni et al. The absence of IJV flow and negative difference in the cross sectional area in IJV supine/sitting postures correlates significantly with the patient’s clinical characteristics.

Keywords: , ,
Full text: PDF

Terephthaldiamides Class Synthesis. III. Synthesis of Some N-monosubstituted Terephthaldiamides

Avrigeanu Veronica1, Imre Silvia2, Mircia Eleonora1, Muntean Daniela-Lucia2

1 Departament of Organic Chemistry, Faculty of Pharmacy, University of Medicine and Pharmacy, Tîrgu Mureș, Romania
2 Department of Drug Analysis, Faculty of Pharmacy, University of Medicine and Pharmacy, Tîrgu Mureș, Romania

Introduction: The aim of this experimental paper was the synthesis of some terephthaldiamides, with potential analgesic action.
Material and methods: The reaction consists of acilation of some primary amines, ethanolamine, allylamine, benzylamine, aniline and orthotoluidine, with terephthaloyl chloride. The purified synthesis products were analysed by thin-layer chromatography, mass, IR and UV spectrometry.
Results: The molecular structure of the obtained N-monosubstitute terephthaldiamides was confirmed by spectral analysis.
Conclusions: Five N-monosubstituted terephtaldiamides were synthesized in good yields by condensation of terephtha¬loyl chloride with primary amines.

Keywords: , ,
Full text: PDF

Editor’s Expression of Concern

Sanda-Maria Copotoiu

Editor-in-Chief

The chief editor expresses her concern as to the allegations of plagiarism disseminated on a large field of personal e-mails, some of them accessed without permission and thus abused, as well as on certain political sites. The dissemination was not only regional, but national, and when it was immediately spread on the internet, the damage could only be figured out.
The allegations regarded some articles previously published since 2010 in our journal. It is our conviction that prior to taking such actions, the journal should be officially informed. Thus we would have had the opportunity to analyze the issues.
The allegations were viciously and falsely fathered consecutively by a character who styled himself as a prominent researcher and voluntary justice maker, further intoxica-ting the net.
The electronic format of the journal was used without permission. [More]

Keywords:
Full text: PDF

The Influence of Acute Phase Blood Pressure on Stroke Outcome: To Treat Or Not To Treat?

Szőcs Ildikó1,2, Bereczki D4, Orbán-Kis K1,2, Szász JA2,3, Győri LF5,6, Szatmári Sz2,3

1 Department of Physiology, University of Medicine and Pharmacy, Tîrgu Mureş, Romania
2 2nd Clinic of Neurology, County Emergency Clinical Hospital, Tîrgu Mureș, Romania
3 Department of Neurology, University of Medicine and Pharmacy, Tîrgu Mureş, Romania
4 Department of Neurology, Semmelweis University, Budapest, Hungary
5 1st Clinic of Cardiology, County Emergency Clinical Hospital, Tîrgu Mureș, Romania
6 Department of Cardiology, University of Medicine and Pharmacy, Tîrgu Mureş, Romania

Romania ranks third in stroke mortality among countries reporting vascular statistics. Acute phase blood pressure has a major influence on stroke outcome. This review aims to give an overview of available data regarding the prevalence of extreme (both low and high) values of blood pressure in acute phase of stroke, impact of blood pressure on stroke prognosis, recommendations on the management of blood pressure, available national data, large ongoing internationl trials with possible impact on stroke guidelines.
The consensus of the EUSI panel is that “emergency administration of antihypertensive agents should be withheld unless the diastolic blood pressure is >120 mm Hg or unless the systolic blood pressure is >220 mm Hg. The panel remains concerned by the evidence that aggressive lowering of blood pressure among patients may cause neurological worsening, and the goal is to avoid overtreating patients with stroke until definitive data are available”.

Keywords: , , ,
Full text: PDF

Complex Multitrauma Patient: Head, Thorax, Abdomen and Limbs

Gomotîrceanu F1, Ghiga Dana2, Petrişor M3, Haifa B3, Băţagă T1

1 County Emergency Clinical Hospital, Tîrgu Mureş, Romania
2 Department of Research Methodology, University of Medicine and Pharmacy, Tîrgu Mureş, Romania
3 Department of Medical Informatics and Biostatistics, University of Medicine and Pharmacy, Tîrgu Mureş, Romania

Introduction: Multiple trauma represents the main cause of death in 40–50 years old patients. It requires a rigorous management of the critical patient to ensure a correct order in the performed maneuvers and a maximum efficiency.
Case report: We report a case of a 27 year-old patient with multiple trauma, victim of a train accident. The patient arrives with the presumptive diagnosis of multiple trauma due to train accident, open acute craniocerebral trauma, suspicion of acute subdural hematoma. After the evaluation in the emergency service, the patient was transferred to the Tîrgu Mureş Surgery Clinic, where an emergency intervention was performed. Any of the lesions presented (abdomen, thorax, extremities and head lesions) were able to produce the patient’s death by themselves.
Conclusions: The survival chances of multiple trauma patients increase due to a rigorous management and the application of a standardized evaluation protocol.

Keywords: , ,
Full text: PDF

Livedoid and Gangrenous Dermatitis (Nicolau Syndrome)

Fekete GyL1, Fekete Júlia Edit2

1 Department of Dermatology, University of Medicine and Pharmacy, Tîrgu Mureş, Romania
2 Public Health Center, Tîrgu Mureş, Romania

Livedoid and gangrenous dermatitis is a rare posttherapeutic accident, produced by intravenous, intramuscular or intra-arterial drug injection under an oily or suspension form. It was first described by Stefan G. Nicolau in 1925 after injections of bismuth. The progression of the disease is favorable most cases are cured after 6–8 weeks. We present a clinical case of a patient aged 74 years.

Keywords: ,
Full text: PDF