Introduction: The purpose of this study is to investigate the host-guest interaction in solid state between anthelmintic drug albendazole and random methyl-beta-cyclodextrin using spectrophotometric method.
Material and method: Binary systems between albendazole and random methyl-beta-cyclodextrin were prepared in four molar ratios using two laboratory methods and the host-guest interaction was characterized by Fourier transform infrared spectroscopy.
Results: The absorption spectra of albendazole display some absorption bands in the 1800–1000 cm-1 domain and the absorption spectra of random methyl-beta-cyclodextrin present a wide absorption band the 1200–1000 cm-1 region. In order to examine the spectral changes of the binary systems, five characteristic bands in albendazole spectrum were chosen and their absorbances were represented for each molar ratio of albendazole in the binary systems.
Conclusions: The Fourier transform infrared spectroscopy analysis of the binary system reveals an emphasis of molecular interaction between albendazole and cyclodextrin as the amount of cyclodextrin in the binary system is increasing.