Objective: To analyze the clinico-pathological data of the skin lesions, especially malignant tumors, this study being the first step in a future immunohistochemical and molecular analysis.
Methods: The 3582 cases of benign, malignant, premalignant and tumor-like lesions of the skin, diagnosed during January 2006–December 2010 in the Pathology Department of the County Emergency Clinical Hospital of Târgu Mureş, surgically specimens, were revised and grouped based on histopathological forms.
Results: Epithelial tumors represented 37.32% of all skin tumors. The mesenchymal tumors (30.29%) were followed by melanocytic tumors (12.45%) and lymphomas (0.39%). Synchronous tumors represented 10.24% of cases. 63.5% of epithelial tumors were malignant, in contrast to 4.52% from mesenchymal tumors. Squamous cell carcinomas (SCC) and basal cell carcinomas (BCC) were predominant, both of them affecting the upper half of the face. SCC especially occured in males (60.98%), but BCC were more frequent in females (50.84%).The average age was 71.30±11.92 years in SCC, and 68.15±11.29 years in BCC respectively. Regarding cutaneous melanomas, females (58.09%) were more affected than males (41.09%). The average age was 61.04±14.35 years. The trunk was the most common location in males, and the lower limb in females. Regarding lymphomas, only Mycosis fungoides was diagnosed.
Conclusions: Most tumors of the skin are malignant epithelial tumors, but mesenchymal tumors are rather benign type. Melanomas are mostly related to the sun exposure, the trunk and lower limb being more involved. In a significant percentage of cases synchronous tumors can develop. Further immunohistochemical and molecular studies are necessary to elucidate the differences between single and synchronous tumors and gender-related characteristics.