Terephthaldiamides Class Synthesis. III. Synthesis of Some N-monosubstituted Terephthaldiamides

Introduction: The aim of this experimental paper was the synthesis of some terephthaldiamides, with potential analgesic action.
Material and methods: The reaction consists of acilation of some primary amines, ethanolamine, allylamine, benzylamine, aniline and orthotoluidine, with terephthaloyl chloride. The purified synthesis products were analysed by thin-layer chromatography, mass, IR and UV spectrometry.
Results: The molecular structure of the obtained N-monosubstitute terephthaldiamides was confirmed by spectral analysis.
Conclusions: Five N-monosubstituted terephtaldiamides were synthesized in good yields by condensation of terephtha¬loyl chloride with primary amines.