Category Archives: Review

New Perspectives: Quinolones as Complexation Agents

Rusu Aura, Gyéresi Á., Hancu G.

University of Medicine and Pharmacy Târgu Mureş, Faculty of Pharmacy, Department of Pharmaceutical Chemistry

Background: Quinolones are synthetic antibacterial agents, with a 4-oxo-1,4-dihydroquinolinic structure, which is based on the nalidixic acid model. The 4-oxo and 3-carboxyl groups confer quinolones excellent chelatation properties with metallic ions.
Aim: To highlight a few theories regarding the complexation phenomenon of quinolones.
Methods: Complexes with metallic ions have been characterized (stoichiometry, in vitro physical-chemicals properties, stability studies, and behavioral studies in different biological mediums).
Results: New availabilities have been identified: bioavailability of the complexed quinolones and formulation of new pharmaceutical products with a superior bioavailability and therapeutic effect; the antimicrobial activity of quinolone complexes; quinolone complexes as antitumor drugs with the aim of obtaining less toxic compounds; understanding the mechanism of action of quinolones, which is a challenge especially regarding their selectivity at the bacterial DNA level; development of new determination methods, based on the complexation of quinolones with metallic ions.
Conclusions: The 21st century may provide new useful therapeutic aspects on the basis of complexation between quinolones and metals.

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Marfan Syndrome: the Nowadays of a Century-old Disease

Seres-Sturm L jr.1, Deac R2, Szabolcs Z3

1 Department of Cardiac Surgery, University of Pecs, Hungary
2 Cardiovascular and Transplant Surgery Clinic, University of Medicine and Pharmacy Targu-Mures, Romania
3 Department of Cardiac Surgery, Semmelweis University Budapest, Hungary

The review emphasizes the actuality and importance of Marfan syndrome research worldwide. The hundred years old disease has been described mainly by its skeletal, ocular and cardiovascular manifestations, and constitutional type. The underlying gene mutations have been discovered in 1991. The surgical treatment of aortic root dilatation and dissection using Dacron tube reconstruction in emergency and prophylactic surgery has been published in 1955. Nowadays international foundations, database networks subjected Marfan syndrome as a rare disease with privileged research programs. The clinical Ghent nosology of pleiotropic criteria is accepted
world-wide (1996). The research programs are focused on international proposals.

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Eco Doppler Examination in Pregnancies with Fetal Growth Restriction

Grif Caterina-Miladi

University of Medicine and Pharmacy, Department of Obstetrics and Gynecology 2, Tîrgu Mureș

Fetal growth restriction remains a major cause of perinatal morbidity and mortality in modern obstetric practice. Doppler velocimetry provides a wide array of information on maternal, fetal, and placental aspects of intrauterine growth restriction (IUGR). Delivery is the only practical treatment option, and the timing of delivery must be aimed to maximize gestation while minimizing the risks of continued intrauterine life. The investigation of the fetal circulation using eco Doppler ultrasonography has become more sophisticated, with greater attention being played to the venous circulation, particularly that unique to the fetus: ductus venosus and the umbilical vein.

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Update in Haematopoietic Stem Cell Transplantation

Berteanu Cristina1, Stoica Maria2, Stoica GA2, Cernea Daniela2, Tănase Alina3, Copotoiu Sanda-Maria4, Brânzaniuc Klara4, Azamfirei L4, Cirstoiu C1, Rosin A5

1 Fundeni Bone Marrow Transplant Center Fundeni
2 Bucharest Emergency University Hospital
3 University of Medicine and Pharmacy of Tîrgu Mureș
4 Craiova Emergency University Hospital
5 Bucharest Institute of Haematology

The authors review the most important aspects of stem cell transplantation, starting with its objectives, general guidelines and specific issues in rare diseases, and series of complications arising from this complicated therapeutic procedure.
Introduction
In the 40 years since the first bone marrow transplant for the treatment of a patient suffering from a congenital immune deficiency, this therapeutic modality has become an option to be considered in the treatment of several haematologic, immunologic, metabolic and neoplastic disorders. This has been possible thanks to the progress in our knowledge of the major histocompatibility complex, the supportive therapy for patients with severe pancytopenia and the prevention and treatment of infections and other complications associated to transplantation [1].
Today, Haematopoietic Stem Cell Transplantation (HSCT), in its different modalities, is the treatment of choice in several malignant and non-malignant haematological diseases and one of the best options in many others [1].[More]

 

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Emergency Anaesthesia for Multiple Trauma

Grinţescu Ioana Marina, Ungureanu Raluca, Mirea Liliana

Anaesthesia and Intensive Care Clinic, Clinical Emergency Hospital, Bucharest, Romania

Trauma anaesthesia management is a challenge because we must deal with a critical ill patient with unclear history, injuries and physiologic status. ATLS® protocol is a useful tool in assessing and managing patients with complex and life threatening injuries. Rapid sequence of intubation is the preferred approach for airway control. Many factors combine to increase tracheal intubation difficulty in the trauma patient. Fluid management is especially challenging because of rapid, unpredictable changes in volume status and incomplete pre-operative resuscitation. For severely injured, the damage control resuscitation approach is intended to minimize exacerbating the multifactorial trauma-induced coagulopathy by replacing lost blood with plasma and platelet-containing products (haemostatic resuscitation) instead of using early and large amounts of crystalloids and RBCs (hypotensive resuscitation). This strategy encapsulates also the established concept of damage control surgery in the scope to rapid control the haemorrhage.

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Possibilities and Challenges in the Molecular Diagnosis Of Lysosomal Storage Disorders

Csép Katalin1, Drugan Cristina2, Bănescu Claudia1

1 Department of Genetics, University of Medicine and Pharmacy, Tîrgu Mureș, Romania
2 Department of Biochemistry, University of Medicine and Pharmacy, Cluj-Napoca, Romania

In inherited metabolic diseases, the final diagnosis is generally made by classic biochemical methods, despite the monogenic etiology. In lysosomal storage disorders, the suspected clinical diagnosis is confirmed by enzyme assay, and DNA analysis is not mandatory for the diagnosis or initiation of the treatment. Like in most enzyme deficits, the inheritance is recessive (autosomal or X-linked). Genetic heterogeneity is characteristic, and hundreds of alleles of the same gene may exist, caused by various mechanisms or mutations at different nucleotide levels. Besides the targeted analysis of the most frequent mutations (N370S, L444P, R463C, 84GG, recNciI, recTL) in Gaucher disease carried out in the national diagnostic center, often mutation scanning and sequencing is required. Though data must be carefully interpreted, molecular testing may provide important additional information, and it is the basis of carrier testing and prenatal diagnosis. The genotype-phenotype correlation remains inconclusive in most of the cases, though sometimes it can be used as a prognostic marker.

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The Influence of Acute Phase Blood Pressure on Stroke Outcome: To Treat Or Not To Treat?

Szőcs Ildikó1,2, Bereczki D4, Orbán-Kis K1,2, Szász JA2,3, Győri LF5,6, Szatmári Sz2,3

1 Department of Physiology, University of Medicine and Pharmacy, Tîrgu Mureş, Romania
2 2nd Clinic of Neurology, County Emergency Clinical Hospital, Tîrgu Mureș, Romania
3 Department of Neurology, University of Medicine and Pharmacy, Tîrgu Mureş, Romania
4 Department of Neurology, Semmelweis University, Budapest, Hungary
5 1st Clinic of Cardiology, County Emergency Clinical Hospital, Tîrgu Mureș, Romania
6 Department of Cardiology, University of Medicine and Pharmacy, Tîrgu Mureş, Romania

Romania ranks third in stroke mortality among countries reporting vascular statistics. Acute phase blood pressure has a major influence on stroke outcome. This review aims to give an overview of available data regarding the prevalence of extreme (both low and high) values of blood pressure in acute phase of stroke, impact of blood pressure on stroke prognosis, recommendations on the management of blood pressure, available national data, large ongoing internationl trials with possible impact on stroke guidelines.
The consensus of the EUSI panel is that “emergency administration of antihypertensive agents should be withheld unless the diastolic blood pressure is >120 mm Hg or unless the systolic blood pressure is >220 mm Hg. The panel remains concerned by the evidence that aggressive lowering of blood pressure among patients may cause neurological worsening, and the goal is to avoid overtreating patients with stroke until definitive data are available”.

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New Therapeutic Perspectives in Hypertension Treatment

Makó Katalin

2nd Department of Internal Medicine, University of Medicine and Pharmacy, Tîrgu Mureș, Romania

Despite the many therapeutic options available today for the treatment of hypertension, a large number of patients remain uncontrolled. The classic antihypertensive therapies including β-blockers, diuretics, calcium channel blockers and the wide class of renin–angiotensin–aldosterone system blockers (converting enzyme inhibitors, angiotensin receptor blockers, renin inhibitors, and mineralocorticoid receptor blockers), are variably successful in achieving the target blood pressure values in hypertensive patients. Although these numerous, safe and effective pharmacologic therapies are available to treat hypertension, novel therapeutic approaches are warranted to improve the management and prognosis of patients with this condition. Several lines of research suggest promising results based on novel pharmacologic and device-based approaches that may treat effectively resistant hypertension and target organ damage in the future. A large number of the new therapeutic strategies are related to renin angiotensin aldosterone system (RAAS). Modulation of the RAAS provides the rationale for current new antihypertensive drugs already used in clinical practice, including eplerenone and aliskiren. The combined angiotensin-converting-enzyme and neutral endopeptidase blockade decreases blood pressure, aldosterone synthase inhibitors improve tolerability in aldosterone antagonism, prorenin-receptor blockers could prevent the angiotensin-independent actions of renin. In the past few years new minimally invasive surgical procedures like carotid baroreceptor activation and renal symphatetic denervation were developed and could be a therapeutic option for patients with uncontrolled hypertension.

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Magnetic Resonance Mammography: Actual Trends and Perspectives

Nechifor-Boila IA1, Buruian M1, Borda Angela2

1 Department of Radiology and Medical Imaging, County Emergency Clinical Hospital, Tîrgu Mureș, Romania
2 Department of Histology, University of Medicine and Pharmacy, Tîrgu Mureș, Romania

Introduction: Magnetic Resonance Mammography (MRM) is a new radiologic examination with wide perspectives in breast cancer diagnosis. We performed a systematic review of the literature, in order to obtain a clear view on the actual role of MRM, together with an accurate evaluation of its performance in clinical settings.
Material and methods: We conducted a thorough PubMed search, both directly and through MeSH (Medical Subject Headings), using specific keywords. We then applied the following filters: articles published only between 1999 and 2011 and written in English or French. Priority was given to reviews and clinic trials according to previously set criteria.
Results: We evaluated the clinical efficiency of MRM using sensitivity, specificity and predictive values (positive and negative). Sensitivity varied between 81 and 98%, while specificity had a much wider dispersion (65–93%), thus supporting the statement that MRM is a sensitive but not a specific examination. Diffusion MRM was comparable to standard MRM, while spectroscopy showed a low sensitivity and a high specificity.
Conclusions: MRM is a complex investigation, with well documented recommendations and good sensitivity. Diagnostic specificity remains an important issue, but with improvement perspectives from new techniques like diffusion and spectroscopy.

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The Role of the General Practitioner in Detection and Control of Tuberculosis

Ács Valeria1, Ianosi Edith Simona2

1 Doctoral School, University of Medicine and Pharmacy, Tîrgu Mureş, Romania
² Department of Pulmonology, University of Medicine and Pharmacy, Tîrgu Mureş, Romania

In Romania, the detection, diagnosis, treatment and prophylaxis of tuberculosis (TB) is being preformed according to the “National Strategy for TB Control 2007–2011”, part of the National Program for the Control of TB 2007–2011 that has been approved by Government Decree. The program has been developed by Romanian experts and it observes the WHO requirements regarding the Global Control of TB in the world. The National Strategy for TB Control aims to maintain a 100% coverage of the WHO DOTS (Directly Observed Therapy in Short course) strategy for prevention of abandon, failures and disorganized treatments with missed doses that may lead to development of chemoresistant strains. It is obvious that the family physician in direct contact with the population is the most suitable to identify TB suspects and their contacts, and to contribute to the correct progress of the outpatient treatment of TB.

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