Tag Archives: cirrhosis

Hereditary hemochromatosis: Retrospective study on clinical data from Emergency County Hospital Mures

Victor Sigmirean

Emergency County Hospital Mures, Targu Mures, Romania

DOI: 10.2478/amma-2022-0031

Objective: Hereditary hemochromatosis, or primary hemochromatosis, is a recessive genetic liver disorder caused by iron accumulation in tissues. This study evaluates patients with hereditary hemochromatosis to determine correlations between clinical and laboratory data.
Methods: The data analyzed in this study was gathered from the discharge records from 2019 to 2021 of the Gastroenterology Department of the Mures Country Emergency Clinical Hospital. 15 patients with hemochromatosis were sampled during the studied period.
Results: Hepatic cirrhosis is present in 67% of the studied group of patients, 40% of patients presented hypertension and 20% of patients showed diabetes mellitus and portal hypertension. Positive correlations were obtained between serum iron and alkaline phosphatase (r=0.8536), between serum iron and lactate dehydrogenase (r=0.7381), and between serum iron and urea (r = 0.79). Positive, strong correlation between ferritin and serum iron (r=0.7719), GOT (r=0.778) and GPT (r=0.6108). total bilirubin and direct bilirubin (r = 0.85), between total bilirubin and GOT (r = 0.68) and GPT (r = 0.82).
Conclusions: Excess iron stored is influencing organ function trough reactive oxygen species, the hepatic signs being a main participant in the clinical presentation, while serum iron cause damage to other tissues such as myocardium, pancreas and kidneys. Treatment for hemochromatosis includes phlebotomies, and iron chelation with Deferoxamine.

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Relationship Between Genotypes of Hepatitis C Virus and the Progression to Cirrhosis in Chronic Hepatitis C Patients

Colțescu Camelia1, Doffoel M1, Habersetzer F1, Oltean G2, Copotoiu Ruxandra3, Georgescu D4, Bățagă Simona4

1 Department of Hepato-gastroenterology, Faculty of Medicine, University Louis Pasteur, Strasbourg, France
2 Department of Internal Medicine, Medical Clinic 1, Faculty of Medicine, University of Medicine and Pharmacy, Tîrgu Mureş, Romania
3 Department of Anesthesiology, Faculty of Medicine, University of Medicine and Pharmacy, Tîrgu Mures, Romania
4 Department of Gastroenterology, Medical Clinic 1, Faculty of Medicine, University of Medicine and Pharmacy, Tîrgu Mureş, Romania

Objective: To assess the influence of the identified genotype on the stage of liver fibrosis at hepatitis C identification and at the 5 years follow up.
Methods: In our retrospective study we enrolled 126 patients with Hepatitis C admitted to the Gastroenterology Unit at the Nouvel Hopital Civil in Strasbourg, France between October 2006 and December 2011. All patients had detectable serum HCV-RNA and had not been transplanted during the 5 years surveillance period. The data collected were analyzed with GraphPad Prism Demo for descriptive and inferential statistics and with StatMate2Demo for power analysis.
Results: In our retrospective study we enrolled 126 patients. Genotype distribution was as follows: genotype 1a, n=23 (18.25%); genotype 1b, n=48 (38.10%); genotype 2, n=17 (13.50%); genotype 3, n=18 (14.29%) and genotype 4, n=20 (15.86%). Fibrosis at diagnosis and follow up was not influenced by the genotype (odds ratio ranging from 0.395 to 5.147 but with a 95% CI below 1), except genotype 1b (odds ratio 2.093 [1.008; 4.348] at follow up).
Conclusions: There is no association between a particular HCV genotype and the fibrosis stage as defined by transient elastography.

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Relationship Between Genotypes of Hepatitis C Virus and the Progression to Cirrhosis in Chronic Hepatitis C Patients

Colțescu Camelia1, Doffoel M1, Habersetzer F1, Oltean G2, Copotoiu Ruxandra3, Georgescu D4, Bățagă Simona4

1 Department of Hepato-gastroenterology, Faculty of Medicine, University Louis Pasteur, Strasbourg, France
2 Department of Internal Medicine, Medical Clinic 1, Faculty of Medicine, University of Medicine and Pharmacy, Tîrgu Mureş, Romania
3 Department of Anesthesiology, Faculty of Medicine, University of Medicine and Pharmacy, Tîrgu Mureş, Romania
4 Department of Gastroenterology, Medical Clinic 1, Faculty of Medicine, University of Medicine and Pharmacy, Tîrgu Mureş, Romania

 

Objective: To assess the influence of genotype on the stage of liver fibrosis in case of hepatitis C at the moment of identification and at the 5 years follow-up.
Methods: In our retrospective study we enrolled 126 patients with hepatitis C admitted to the Gastroenterology Unit of the Nouvel Hopital Civil in Strasbourg, France between October 2006 and December 2011. All patients had detectable serum HCV-RNA and had not been transplanted during the 5 years surveillance period. The collected data was analyzed with GraphPad Prism Demo for descriptive and inferential statistics and with StatMate2Demo for power analysis.
Results: Genotype distribution was as follows: genotype 1a, n=23 (18.25%); genotype 1b, n=48 (38.10%); genotype 2, n=17 (13.50%); genotype 3, n=18 (14.29%) and genotype 4, n=20 (15.86%). Fibrosis at diagnosis and follow-up was not influenced by the genotype (odds ratio ranging from 0.395 to 5.147 but with a 95% CI below 1), except genotype 1b (odds ratio 2.093 [1.008; 4.348] at follow-up).
Conclusions: There is no association between a particular HCV genotype and the stage of fibrosis as defined by transient elastography.

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