There are a few skin lesions which are conected with internal malignancies, being important especially if they appear prior to neoplasia.
We are presenting the case of a patient who had desquamative erythrodermia associated to lung carcinoma. The patient was also diagnosed with a cerebral metastasis. The appearance of skin lesions suggested the presence of a subacute immune vasculitis, this was confirmed by immunohystochemical examinations, which revealed a leukocytoclastic vasculitis. Given the fact that previous erythematous lesions improved during the treatment of cerebral metastasis, the reccurence of erythrodermia suggests the evolution of metastasis. On the other hand, we can not rule out the possible role of the received chemotherapy in the development of the vasculitic process. The observation that these events do not occur in all cancer patients leads to the conclusion that the triggering mechanisms responsible for these paraneoplastic syndromes are individually conditioned.