Background: Soybean is the vegetal product of soy, Glycine max fam. Fabaceae. It is well known that short-term ingestion of raw soy and plant trypsin inhibitors by mice greatly stimulates the exocrine pancreas, leading to increased enzyme production, organ enlargement and cellular hyperplasia.
The aim of this study is to examine changes that occur in the liver, an organ from the gastrointestinal tract less studied on this topic when row soy is administrated. Short time nutritional studies were conducted on C57BL/6J mice of four weeks.
Results showed a decrees in mice body mass after administration of row soybean. Histological analyze revealed an alteration of the pancreas showing the presence of inflammatory cell infiltrate, the phenomen of vascular congestion and edema of the parenchymal cells and of the liver highlighting fibrosis of the vascular wall, the presence of the intravascular infiltrate represented by fibrin and figurative elements (erythrocytes and leukocytes), of the Kupffer cells phagocyte active, and granulocytes with diapedez trend.
Conclusions: The main conclusion of this study is that row soybean diet has a negative action on the gastrointestinal tract in animal model affecting mostly the pancreas and the liver translated by decreasing body weight in mice.