Tag Archives: risk factors

Obesity and Calcium Oxalate Renal Stones

Nicola Th1, Dobreanu Minodora2, Buda Brîndușa3, Oșan V4, Gliga Florina3, Satan Edit1

1 Department of Laboratory Medicine, County Emergency Clinical Hospital, Tîrgu Mureș, Romania
2 Department of Laboratory Medicine, University of Medicine and Pharmacy, Tîrgu Mureș, Romania
3 Department of Pathophysiology, University of Medicine and Pharmacy, Tîrgu Mureș, Romania
4 Department of Urology, University of Medicine and Pharmacy, Tîrgu Mureș, Romania

Introduction: Kidney stones are a major cause of morbidity. The lifetime prevalence of symptomatic renal stones is approximately 10% in men and 5% in women. The rate of backsliding for calcium oxalate stones is 10% in one year, 30% in 5 years and 50% in 10 years. Urine pH is one of the important factors for urinary stone formation.
Material and methods: We studied 283 renal stone formers (131 men, 152 female), divided according to their BMI (body mass index) in normal body weight (BMI <25 kg/m2), overweight (BMI 25–30 kg/m2) and obese (BMI >30 kg/m2).
Results: Urine pH is inversely related to BMI among patients with urolithiasis (higher BMI will have lower urine pH). The mean urine pH of the normal body weight, overweight, and obese groups was 6.1, 5.5 and respectively 5.7 (p <0.0001).
Conclusions: Obesity is associated with both hypercalciuria and with proteinuria, demonstrated factors in the etiology of urolithiasis, and urinary pH is inversely related to BMI in patients with urinary stones.

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The Characteristics of Amiodarone-induced Thyrotoxicosis in a Moderate Iodine Deficit Area

Cota Ancuța-Elena1, Căpraru Oana-Maria1,2, Pașcanu Ionela1

1 Department of Endocrinology, University of Medicine and Pharmacy, Tîrgu Mureș, Romania
2 Department of Physiology, University of Medicine and Pharmacy, Tîrgu Mureș, Romania

DOI: 10.2478/amma-2013-0045

Introduction: Amiodarone (AMI), a class III anti-arrhythmic drug, is associated with a number of side effects, including thyroid dysfunction (both hypo- and hyperthyroidism), which is due to amiodarone’s high iodine content and its direct toxic effect on the thyroid.
Objective: To evaluate the incidence of Amiodarone induced thyrotoxicosis (AIT) (type, rate of occurrence) and to identify the risk factors involved in its occurrence.
Material and method: We examined patients treated with amiodarone, between January 2002 and December 2011, who presented to our Department of Endocrinology Târgu Mures for thyroid dysfunctions.
Results: The retrospective study included 87 patients with thyroid dysfunctions; 58 (66.7%) patients had AIT and 29 (33.3%) had Amiodarone induced hypothyroidism (AIH). In the AIT group: 35 were women (60.3%), 23 were men (39.7%); the average age was 61.60 ± 12.39 years. Risk factors identified for the AIT group were male gender (RR = OR = 3.8; Chi-squer = 5.7, p = 0.004) and pre-existing thyroid abnormalities (RR = 2.5, Chi-square = 4.1, p = 0.005). The thyroid dysfunction occurrence was heterogeneous (0.2–183 months). The patients with previous thyroid abnormalities developed earlier thyroid dysfunction compared to those with an apparently normal thyroid gland (22.25 ± 4.14 months versus 32.09 ± 7.69 months, p = 0.02, T test).
Conclusion: In the context of the specific iodine geoclimatic intake and the area of origin, amiodarone – induced thyroid dysfunction spectrum is dominated by thyrotoxicosis. Screening and monitoring of thyroid function for patiens under chronic amiodarone treatment is necessary.

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Prevalence of Physiological, Pathological and Behavioral Risk Factors in Patients Treated with Antidiabetic Sulfonylureas

Confederat Luminita*, Stefan Roxana, Constantin Sandra, Hăncianu Monica, Profire Lenuta

University of Medicine and Pharmacy “Grigore T. Popa”, Iași , Romania

DOI: 10.1515/amma-2015-0080

Diabetes mellitus is an important public health problem because of its increased incidence and its devastating complications. In addition to this, it was observed an increase in prevalence for diabetes risk factors. The aim of this study was to evaluate the frequency of the pathophysiological and behavioral risk factors among patients treated with oral hypoglycemic sulfonylureas.
Material and methods: It were analyzed the observation sheets of 200 patients ambulatory treated at the “Providența” Medical Center.
Results and discussions: Most of the patients were aged over 65 years, being 48.5% women and 51.5% men. The obesity was the most frequent (88%) risk factor in patients; the majority of them were included in the “overweight” and “first- degree obesity” class (72%). Regarding associated comorbidities, hypertension was found in 77% of cases, followed by dyslipidemia. In terms of physiological and behavioral aspects, age and alcohol consumption were predominant.
Conclusions: A significant percentage of diabetic patients treated with hypoglycemic sulfonylureas present a high prevalence of the risk factors and even two or three factors associated.

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