The prevalence of contact dermatitis (CD) in Europe varies between 6.7% and 10.6% depending on the sector of activity. Professional CD (PCD) has an important economic impact – 30% of the budget compensation for occupational disease. In Romania, the prevalence of PCD is underestimated, with an even distribution of cases with respect to the allergic or irritative mechanism. A retrospective clinical study was conducted; target population being the patients admitted in Occupational Medicine Clinic Cluj-Napoca between 2003 and 2011. Objectives of study were: specifying the prevalence range of allergic CD (ACD) / irritative CD (ICD) among occupational/work-related diseases, the distribution of allergic/irritative CD (A/ICD) for different sectors of activity and establishing the correlation between atopy and A/ICD. We have applied allergy skin tests – prick (environmental allergens) and patch (occupational allergens). Inclusion criteria were: -documented occupational exposure at skin allergens/irritants; -the atopy state; -diagnostic established at discharge. Patients with recurrent chronic urticaria, angioedema, hypereosinophilic syndrome have been excluded. Statistical analysis was done using SPSS software. The study indicated a similar prevalence for A/ICD, with similar distribution. Prevalence above average has been recorded in the metallurgy sector (A/ICD), in health care sector (ACD), respectively, textile industry (ICD). The correlation atopy-ACD has proved to be lower compared to previous reports. Regarding ICD, the diagnostic was confirmed frequently to non-atopic persons. We strongly recommend the compliance with a multidisciplinary protocol for the management of A/ICD, individualized for specific activity sectors or even work stations.