Category Archives: AMM 2025, Volume 71, Number 2

Comparative non-invasive strategies for managing dental white spot lesions: Contribution to the study of enamel remineralization

Alessandro Golia1, Alessandro Stellino1, Nicola D’Andrea1, Oana Elena Stoica2, Kovács-Ivacson Andrea Csinszka3, Monica Dana Monea3, Alexandra Mihaela Stoica3

1. Faculty of Dental Medicine, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, Romania
2. Department of Pedodontics, Faculty of Dental Medicine, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, Romania
3. Department of Odontology and Oral Pathology, Faculty of Dental Medicine, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, Romania

DOI: 10.2478/amma-2025-0015

White spot lesions (WSLs) are an early sign of enamel demineralization, requiring effective non-invasive treatments to restore esthetics and prevent progression. This study aimed to evaluate the effectiveness of fluoride varnish (GC MI Varnish) and resin infiltration (Icon Vestibular) in terms of esthetic improvement, remineralization, and sensitivity reduction. The study is primarily addressed to general dental practitioners, pediatric dentists, orthodontists, and restorative specialists who routinely encounter white spot lesions (WSLs) in both adolescent and adult patients. It is also relevant to dental researchers and students interested in minimally invasive treatment strategies and advancements in enamel remineralization. A total of 47 patients with non-cavitated WSLs were randomly assigned to two treatment groups: Fluoride Group (n = 24) received topical fluoride varnish applications and Icon Group (n = 23) underwent resin infiltration treatment. Statistical analysis was performed using an independent t-test (p < 0.05). The Icon Group showed an immediate reduction in white spot visibility (p < 0.01), while the Fluoride Group demonstrated gradual esthetic improvement over three months (p < 0.05). Fluoride varnish significantly enhanced enamel remineralization and reduced dentinal hypersensitivity (p < 0.05), whereas resin infiltration primarily stabilized lesion progression without direct remineralization. Both fluoride varnish and resin infiltration are effective non-invasive treatments for WSLs, but their benefits differ. Resin infiltration offers immediate esthetic improvement, while fluoride varnish promotes long-term remineralization and sensitivity reduction.

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Prescription of antibiotics in bone augmentation with dental implant

Omar W. Saleh1, Bashar A. Tawfeeq2, Rawaa Y. Al-Rawee3

1. Department of Dental Basic Sciences, college of Dentistry, Mosul University , Nineveh, Iraq
2. Department of Maxillofacial Surgery, College of Dentistry, Al-Noor University, Nineveh, Iraq
3. Department of Maxillofacial Surgery, Al-Salam Teaching Hospital, Nineveh Health Directorate, Nineveh, Iraq

DOI: 10.2478/amma-2025-0014

Aim: To evaluate the success and failure in bone augmentation with dental implant cases when antibiotics were used with different timing in long follow-up periods.
Material and Method: 120 patients were randomly put into three groups: (1) no antibiotic treatment (NOAB); (2) preoperative and postoperative antibiotic treatment (PPAB) with 1.5 g of amoxicillin an hour before surgery and 500 mg three times a day for five days after surgery; and (3) postoperative antibiotic coverage (POAB) with 500 mg three times a day starting after surgery and continuing for five days after surgery. We conducted a comparison and follow-up of patients to detect antibiotic responses in the context of bone augmentation and dental implants.
Results: We recorded highly significant differences in age groups and gender. We observed highly significant differences (0.000, 0.000, and 0.041) on the third day, the 12th week, and after six months of follow-up. The results indicated that in group 1, 7 implants (11.6%) failed, while in group 3, only 2 implants (3.33%) failed. In contrast, in group two, all implants succeeded (100%).
Conclusion: The use of preventive antibiotics resulted in a very low infection rate. Conversely, the absence of preventive antibiotics significantly increased the infection rate. A higher number of studies were required to analyze the biological factors that contributed to failure in the case of various antibiotic doses and types.

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Spindle cell angiosarcoma as primary cutaneous tumor – Case report and brief literature review

Andreea Cătălina Tinca1,2, Bianca Andreea Lazar2, Carmen Friciu3, Ovidiu Simion Cotoi1,2

1. Department of Pathophysiology, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, Romania
2. Pathology Department, Mures Clinical County Hospital, Targu Mures, Romania
3. Plastic Surgery Department, Mures Clinical County Hospital, Targu Mures, Romania

DOI: 10.2478/amma-2025-0012

Angiosarcoma is a rare, aggressive malignant tumor of vascular origin, often characterized by rapid growth and infiltrative behavior. While it commonly occurs in the skin, particularly on the scalp of elderly patients, it can also affect other regions. We present a case of a 76-year-old male with a rapidly growing, well-demarcated nodule on the dorsum of the hand, which was excised for pathological examination. Histopathological analysis revealed spindle-shaped tumoral cells with a storiform pattern, poor vascularization, and immunohistochemistry positivity for CD31 and CD34. The case underscores the importance of distinguishing angiosarcoma from other spindle-cell tumors, such as leiomyosarcoma and atypical fibroxanthoma, and highlights the essential role of immunohistochemistry in achieving an accurate diagnosis. Early detection and appropriate surgical management are crucial for optimal outcomes in patients with this aggressive malignancy.

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Happiness-enhancing activities as a mediator between orientations to happiness and positive emotions: A longitudinal study

Alina Ciupei, Ionuț Stelian Florean, Paula Stroian

Babeș-Bolyai University, Cluj-Napoca, Romania

DOI: 10.2478/amma-2025-0013

Objective: Although multiple studies have linked orientations to happiness to various well-being indicators, such as positive emotions, the underlying mechanisms of this relationship remain less understood. Given that orientations represent behavioral tendencies rather than concrete actions, this study aims to explore whether engaging in happiness-enhancing activities mediates their effect on positive emotions.
Methods: At baseline (T0; N = 349), participants completed an online survey assessing their happiness orientations. Over the following three weeks, participants reported their involvement in pleasure-, engagement-, and meaning-enhancing activities and their positive emotions (T1: N = 166; T2: N = 164; T3: N = 129).
Results: Multilevel mediation analyses showed that pleasure-enhancing activities partially mediated the pleasure orientation–positive emotions link (beta coefficient = 0.08, p < 0.05), while engagement-enhancing activities fully mediated engagement orientation (beta coefficient = 0.08, p < 0.05). Meaning-enhancing activities partially mediated the effect of meaning orientation on positive emotions, with a marginally significant indirect effect (β = 0.07, p = 0.050).
Conclusions: Findings suggest that translating happiness orientations into concrete, activity-based behaviors is important for sustaining positive emotions. Engagement orientation appears to rely fully on active participation in engagement-enhancing activities, while pleasure and meaning orientations benefit from such activities but may also be influenced by cognitive processes or other psychological mechanisms.

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