Category Archives: Letter to Editor

Nucleostemin and p-STAT3 as early diagnostic potential markers in oral squamous cell carcinoma

DOI: 10.2478/amma-2023-0050

Oral cancer is considered the sixth most common type of cancer worldwide, out of which India contributes to about one-third of the total cases [1]. Oral squamous cell carcinoma (OSCC) is the most dominant of all oral cancer cases and may develop from a potentially malignant disorder with a detectable pre-clinical phase. The primary causes of OSCC include tobacco consumption that involves smokeless tobacco, chewing of betel-quid and excessive consumption of alcohol, unhygienic oral practices, periodontal diseases, and sustained viral infections caused by human papillomavirus (HPV) [2]. Instead of these traditional risk factors (alcohol consumption and cigarette smoking), oncogenic HPV is found to be the main causative factor for the increasing incidence of OSCC. Furthermore, HPV etiology is linked to increased survival following conventional treatments. [More]

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The First International Western and Chinese & Thai Medicine Workshop on Pain Therapy & Management, Targu Mures, Romania. November 25 – 28, 2019

DOI: 10.2478/amma-2020-0005

The First International Workshop on using combined Western and Traditional Medicine for Pain Therapy was successfully held in Romania, 2018. Medical doctors from Romania, China and Thailand participated as lecturers and demonstrators to more than 40 participants. At the conclusion of the workshop, the organizers, lecturers and participants overwhelmingly endorsed the proposals to organize the second workshop and to organize a clinical trial in developing a combined protocol for innovative pain therapy.

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Romanian Translation and Cross-Cultural Adaptation of the SarQol Questionnaire

DOI: 10.1515/amma-2016-0036

Sarcopenia, or age-related muscle loss is emerging as a major public health concern. A reduced quality of life (QoL) due to impaired physical performance associated with this disease has been evidenced in these individuals.Generic instruments, such as Short Form 36 questionnaire (SF-36), do not accurately assess the impact of sarcopenia on QoL. SarQol (Sarcopenia Quality of Life) questionnaire, was the first disease-specific questionnaire addressing quality of life in patients with sarcopenia and has been recently designed for providing a global picture on quality of life in community-dwelling elderly subjects aged 65 years and older. Our aim was the translation and cultural adaptation of the original SarQol, to finally obtain a highly reliable instrument for the assessment of the quality of life of Romanian patients, affected by sarcopenia.
We followed the recommended process, the international protocol of translation. The pretest process involved 20 subjects (10 sarcopenic and 10 non sarcopenic with different educational and socioeconomic backgrounds) who were asked to complete the questionnaire. Feedbacks were requested from all subjects regarding the clearness of questions, difficulties in completing the test or understanding the meaning of questions. Using the recommended best practice protocol for translation, the pre-final version is comparable with the original instrument in terms of content and accuracy. After the validation of psychometric properties, it should be a useful tool to assess Quality of Life and sarcopenia among elderly Romanian patients.

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The Osteoprotegerin – Von Willebrand Factor Complex: Protagonist Or Bystander In Atherothrombosis?

DOI: 10.1515/amma-2016-0012

Two important cardiovascular risk factors, osteoprotegerin and Von Willebrand Factor form complex in endothelial cells and in circulating blood. The pathophysiological role of the complex is unknown. We give a brief review of the relevant literature and confront it with some of our recent findings regarding the OPG-VWF correlation.

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A Short Review of the Experience of the University of Medicine and Pharmacy of Tîrgu Mureş in Medical Simulation

DOI: 10.1515/amma-2015-0109

Medical simulation is used in a growing number of medical education institutions all over the world. Since 2013, the University of Medicine and Pharmacy of Tîrgu Mureş has introduced a number of simulation methods into the curriculum of certain subjects, the number of which is expanding. This article sums up some of the knowledge available in the literature regarding medical simulation and presents the general framework under which it is used in medical learning in our University.

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Successful Reversal with Sugammadex of Deep Neuromuscular Block Caused by Rocuronium and Magnesium Sulfate in a Patient with H.E.L.L.P Syndrome

A 70 kg, previously healthy, 28-year-old primigravida was admitted to our delivery ward at 36 weeks of gestation. The patient was suffering from severe preeclampia with H.E.L.L.P (hemolysis, elevated liver enzymes and low platelets count) syndrome. She was treated with magnesium sulfate 4 g bolus followed by 2 g/h continuous infusion (her magnesium plasma levels were 5-6 mg%) and hydralazine but, since her clinical status was worsening (severe hypertension and decreasing platelets count from 80,000 to 40,000/µL), an urgent Caesarean delivery was planned. In view of the low platelet count it was decided to perform general anesthesia using a rapid-sequence induction with propofol 3 mg/kg and succinylcholine 1.5 mg/kg. Standard anesthetic monitoring included a nerve stimulator (TOF-Watch SX, Organon- Technika Boxtel, the Netherlands) with the active electrode attached over the ulnar nerve. Anesthesia was maintained with 1-2% isoflurane in a mixture of 50% oxygen/nitrous oxide. Fentanyl 100 mcg was administered after the baby was delivered and the umbilical cord was clamped. [More]

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Preventive Medicine

Although doctors, in the Hippocratic oath, give faith both to goddesses Hygeia (the goddess of health and prevention) and Panacea (goddess of healing), in practice they give a preferential attention to healing. Thousands of years ago the Chinese, appreciating the advantages of disease prevention, did not pay doctors until they would apply profilactic measures efficiently [1]. In the Middle Ages, profilactic measures addressed to collectivities, through vaccination of the population against contagious epidemics (smallpox, cholera, etc.) In modern times, the shift of pathology towards chronic diseases (cardiovascular diseases, cancer, diabetes), changes the direction of preventive measures from collective prevention to individual prevention. In 1983, in the US, individual preventive measures were merged with collective preventive measures, in a specialty called “Preventive Medicine and Public Health”[2].
In Romania, preventive communities belong to “Public Health and Health Management”. Individual preventive measures are carried out especially by family physicians and episodically, ambulatory physicians.
In the following we present our observations regarding preventive medicine.[More]

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Genetics of Pain

DOI: 10.2478/amma-2013-0054

Pain is ”an unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage” [2]; it is a common problem, not only for patients, but also for the medical world.
Nociceptive pain has a protective role, a signal role, but if the lesions that caused it persist and are excessive, pain becomes a disease (neuropathic pain).
The partial failure of integrated treatment methods, especially in the case of chronic diseases, determined scientists to turn their attention towards the genetic conditioning of individual pain perception and the effectiveness or adverse reactions of painkillers or neuroleptic medication.
The financial aspect of treating pais is also of great importance: there are immense sums of money spent annually to treat pain: 150 billion USD in the USA, and 200 billion EUR in Europe [3]. Other pain-related aspects, such as depression (22%) and the loss of jobs (25%) also have to be considered [3].[More]

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