Category Archives: Number

Morphological Changes of the Fetal Hip Joint and Their Effect on the Stability of the Joint During Its Intrauterine Development

Baróti Beáta1, Pánti Z2, Pap Zsuzsanna3, Dénes L3, Pávai Z3

1 Department of Radiology and Imaging, University of Medicine and Pharmacy, Tîrgu Mureş, Romania
2 Student, GM 5th year, University of Medicine and Pharmacy, Tîrgu Mureş, Romania
3 Department of Anatomy and Embryology, University of Medicine and Pharmacy, Tîrgu Mureş, Romania

Background: Hip joint dislocation and dysplasia are frequent congenital malformations with a multifactorial etiology with a major role played by intrauterine mechanical forces during development. Our aim was to define the surface of the femur and acetabulum, and to study the changes in geometrical parameters and the relationships between them during development.
Material and method: In this study we dissected the hip joints of 10 post-mortem fetuses. Fetal age was determined using crown-rump length (CRL) (min. 8.5 cm, max. 30 cm). Then we performed morphological and geometrical measurements on the articular components. We calculated the area of the articular surfaces, then determined the femoral head coverage and compared the antetorsion (AT) of the femur with the AT of the acetabulum.
Results: in the 3 months fetus the surface areas of the femur and acetabulum are almost identical, the femoral head coverage is maximal, and later with age progression the head coverage decreases, as its growth is more intense than that of the acetabulum. During development the increase of femoral AT determines the increase of the acetabular AT.
Conclusions: The decrease in femoral head coverage during development results in a decrease in articular stability. The femoral head’s position and compression plays an important role in the development of the acetabulum.

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The Prognostic Impact of the Karyotype in Patients with Acute Lymphoblastic Leukemia

Bănescu Claudia1, Benedek I2, Duicu Carmen3, Demian Smaranda4, Macarie I4, Voidăzan S5, Dobreanu Minodora6

1 Department of Genetics, University of Medicine and Pharmacy, Tîrgu Mureș, Romania
2 Hematology Clinic 2, University of Medicine and Pharmacy, Tîrgu Mureș, Romania
3 Pediatric Clinic, University of Medicine and Pharmacy, Tîrgu Mureș, Romania
4 Hematology Clinic 1, University of Medicine and Pharmacy, Tîrgu Mureș, Romania
5 Department of Epidemiology, University of Medicine and Pharmacy, Tîrgu Mureș, Romania
6 Department of Clinical Biochemistry, University of Medicine and Pharmacy, Tîrgu Mureș, Romania

Background and Objective: Acute lymphoblastic leukemia (ALL), is characterized by uncontrolled precursor lymphocyte proliferation. Chromosomal abnormalities have been found in 60–85% of ALL patients. The aim of our work was to determine the chromosomal abnormalities and to evaluate the prognostic value of cytogenetic findings in a cohort of ALL patients.
Method: The study included 36 patients with ALL from Hematology Clinics Tg. Mures, Romania. Cytogenetic analyses were done on bone marrow cultures according to standard methods.
Results: We identified 22 cases (71%) with cytogenetic abnormalities. In our study, the frequency of chromosomal abnormalities was 50% in children and 85% in adults. The most common clonal karyotype aberration in ALL patients was numerical chromosomal abnormalities, detected in 62% of cases. Structural chromosomal abnormalities were found in 38% of our cases and were represented by translocations and deletions. We included our patients in different cytogenetic risk groups: 2 patients in low cytogenetic risk group, 23 in intermediate cytogenetic risk and 6 in severe cytogenetic risk group. We did not find a statistically significant difference in the median overall survival (OS) between the three cytogenetic risk groups (p = 0.863).There was a significantly better OS in patients who had a normal karyotype compared to those who had chromosomal abnormalities (p = 0.008).
Conclusion: Our study highlights the importance of cytogenetic analysis as an important prognostic factor in ALL

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Oral Health … From Good to Better

Monica Dana Monea

Department of Odontology and Periodontology, Faculty of Dental Medicine, University of Medicine and Pharmacy, Tîrgu Mureș, Romania

The dental profession is known for working to eliminate dental caries and periodontal disease, but we cannot rest on the laurels of fluoride and electrical toothbrushes. Over the years we witnessed a silent debate as to whether we are really doctors or just dental technicians who clean teeth, deliver porcelain crowns and replace amalgam restorations. From my point of view, a good dentist must be a combination of diagnostician, technician, healer and artist, but if we truly aspire to become health providers, our goal of excellence must aim towards the elimination of dental disease and not just the treatment of its consequences.
In the last 20 years there has been a complete transition from reactive dentistry, which implies treating according to symptoms, to a very much prevention orientated dental profession. This new concept means that instead of reacting to an already established oral health problem, the treatment must focus on preventing dental diseases before irreversible damage to oral hard and soft tissues occurs. [More]

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Chondrodermatitis Nodularis Helicis

Fekete GyL1, Fekete Júlia Edit2

1 Department of Dermatology, University of Medicine and Pharmacy, Tîrgu Mureş, Romania
2 Public Health Center, Tîrgu Mureş, Romania

DOI: 10.2478/amma-2013-0013

Chondrodermatitis nodularis helicis is a rare and well defined clinical condition, characterized by the appearance of painful nodule or nodules located on the helix. Affects mainly white men, aged 50 and more. The pathogenesis of the disease is unclear. The used treatments gives excellent results, but the disease tends to relapse. We present a clinical case of a young man of 38 years of age with a painful nodule located on the left ear.

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