Tag Archives: diastolic dysfunction

Evaluation of Diastolic Function in Patients with Aortic Stenosis

Introduction: Diastolic dysfunction is characterized by an increased resistance to filling with increased diastolic filling pressures. Aortic stenosis has become the most frequent type of valvular heart disease. Aortic stenosis increases diastolic filling pressures due left ventricular hypertrophy.
Material and methods: Our study is a retrospective one, and includes the IV. th Medical Clinic patients discharged in years 2009–2010. Thirty-four patients with severe aortic stenosis (group A), and 21 patients with moderate aortic stenosis (group B) underwent complete paraclinical evaluation.
Results: The mean age in the group A was 70 years, versus 67 years in group B. The left atrium anteroposterior diameter was 46 mm in grop A, and 43 mm in group B. In group A, the mean left ventricular thickness index was 0.51, versus 0.46 in group B. Severe diastolic dysfunction was present in 35% in group A , and in 19% in group B. The most frequent associated pathology was hypertension (35% in group A, 47% in group B).The most common complications were mitral insufficiency (31 patients in group A, 16 patients in group B), pulmonary hypertension (16 patients versus 9 patients).
Conclusions: The severe aortic stenosis was more frequent in advanced ages. The left atrium enlargement, the severe diastolic dysfunction, and a greater left ventricular wall thickness index were more common in patients with severe aortic stenosis. The most common associated risk factors in both groups were hypertension. The mitral regurgitation was more frequent in the severe aortic stenosis group.

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Association of Heart Failure with Preserved Ejection Fraction and Components of Metabolic Syndrome

DOI: 10.1515/amma-2015-0078

The aim of the current study was to find any possible associations between elements of metabolic syndrome and echocardiographic characteristics (grade of diastolic dysfunction) in normoponderal and overweight patients with heart failure with preserved ejection fraction. A retrospective observational analytical study was performed on 130 patients presenting heart failure with documented ejection fraction over 50%. They were divided into two groups based on their body mass index. The first group included 56 normal weight patients and the second group included 74 overweight patients. Elements of the metabolic syndrome analysed in the current study were arterial hypertension, high triglyceride levels, low HDL-cholesterol and diabetes. None of the components of metabolic syndrome alone had a role in the evolution of diastolic dysfunction in either group. Three or four elements present in obese patients were negatively associated with grade 2 diastolic dysfunction, high values of blood pressure (over 180/110 mmHg) were more often encountered in obese patients with first and second grade of diastolic dysfunction.

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