Introduction: Primary intraosseous mucoepidermoid carcinoma is a rare malignancy originating from minor or ectopic salivary gland tissue within the jawbones, presenting diagnostic challenges, especially in young patients. This article is aimed at oral and maxillofacial radiologists, surgeons, oncologists, and dental practitioners who encounter such cases, highlighting the importance of early recognition for effective treatment planning.
Case Presentation: Two cases of primary intraosseous mucoepidermoid carcinoma in the maxilla are presented. The first involves a 27-year-old female with pain and swelling in the left upper jaw. Cone-beam computed tomography showed a multicystic hypodense lesion with bicortical expansion and palatal perforation. The second case features a 15-year-old with similar radiographic findings but with additional lymph node involvement, indicating a more aggressive disease. The first case was localized and painful, while the second was painless, with the lesion extending into the maxillary sinus. Diagnoses were confirmed via fine needle aspiration cytology and histopathology, followed by surgical resection.
Conclusion: These cases highlight the need for clinicians to consider primary intraosseous mucoepidermoid carcinoma as a differential diagnosis for jaw swellings across all ages. Advanced imaging, particularly cone-beam computed tomography, is crucial for precise diagnosis and early intervention, leading to improved patient outcomes.