Category Archives: Number

The impact of the COVID-19 pandemic on the educational process of Dental Medicine Department students in Oradea University during the lockdown period

Gabriela Ciavoi1, Catalina Farcasiu2, Edwin Sever Bechir3, Magdalena Natalia Dina2, Titus Alexandru Farcasiu2, Daniela Ioana Tarlungeanu2, Oana Cella Andrei2

1. University of Oradea, Faculty of Medicine and Pharmacy, Oradea, Romania
2. “Carol Davila” University of Medicine and Pharmacy, Bucuresti, Romania
3. George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, Faculty of Medicine, Targu Mures,
Romania

DOI: 10.2478/amma-2021-0006

Aim: This cross-sectional study assesses the opinions regarding the abrupt change in dental health education of students from the Department of Dentistry, Faculty of Medicine and Pharmacy, Oradea University during the lockdown period.
Materials and methods: An on-line survey was distributed, from 30th of April 2020 until the 2nd of May 2020, collecting data about gender, nationality, year of study, sources of information about the virus, measures taken to avoid contamination, rating online teaching versus face-to face teaching, experiencing anxiety about the future of the profession, perceived impact of the COVID-19 pandemic on their life and professional future and possible measures that can be implemented in order to avoid or reduce contamination. Data was analyzed using IBM SPSS and Chi-Square test.
Results and discussions: Reopening was associated with anxiety concerning the future of the profession for 44.8% of the respondents; almost half of the students experienced anxiety caused by the possibility of being infected in case of reopening (49.7%), while 62.6% were afraid of the possibility to infect their family, peers or patients. From the total number of students, 12.9% were considering changing their profession. A quarter of respondents (25.2%) declared that they will wait for a decrease in number of cases in order to reevaluate their professional career options.
Conclusions: Government provided data was preferred by the female respondents’ group, versus the men respondents’ group who preferred the information provided by the WHO. The highest percentage of respondents that considered professional psychological support from university during the lockdown period useful were in the first 4 years of study. Most of the foreign students preferred to open their own dental office, while most of the Romanian students opted for being an employee in a big Dental Clinic or for reevaluating their options at a later point.

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Protein level alteration of endocannabinoid system components after chronic, oral self-administration of three atypical antipsychotics in rat

László-István Bába1, Melinda Kolcsár1, Zsolt Gáll1, László Csaba Bencze2, Adrian Man3, Imre Zoltán Kun4

1. Department of Pharmacology and Clinical Pharmacy, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, Romania
2. Biocatalysis and Biotransformation Research Center, Faculty of Chemistry and Chemical Engineering, Babeș-Bolyai University, Cluj-Napoca, Romania
3. Department of Microbiology, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, Romania
4. Doctoral School, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, Romania

DOI: 10.2478/amma-2021-0008

Objective: Atypical antipsychotics (AAPs) often cause metabolic adverse effects (mAE) such as weight gain and dyslipidemia. The mechanisms underlying AAP induced mAE are not fully elucidated. The endocannabinoid system (ECS) is a key system in the regulation of energy metabolism that may be involved in AAPs induced mAE. In this experiment, we studied the expression of three major components of ECS: cannabinoid receptor 1 (CB1), fatty acid amidohydrolase (FAAH) and monoacyl glycerol lipase (MAGL) after chronic administration in rat of three AAPs: olanzapine (Ola), aripiprazole (Ari) and cariprazine (Car).
Methods: Drugs were self-administered orally, in two doses by female, adult Wistar white rats (n=6 per treatment group) for six weeks. After the treatment period, the animals were sacrificed and visceral (perirenal) white fat pads were collected. The fat tissue samples were homogenized and the expression level of CB1, FAAH and MAGL were compared by western-blot analysis.
Results: An increase of CB1 expression was noticed after the treatment with 1.5 mg/kg/day Ola, although not statistically significant. All three drugs augmented the FAAH expression, the effect being significant after the treatment with 0.25 mg/kg/day Car. The expression of MAGL was not influenced significantly by the three AAPs, nevertheless, an increasing tendency can be remarked in the case of Ari and Car.
Conclusions: Promoting the CB1 expression in adipose tissue could contribute to weight increasing and other mAE effects of Ola. The tendency of Ari and Car to enhance the breakdown enzymes expression might have some role in more favorable mAE of these drugs.

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Metatypical Carcinoma – A Continuous Challenge for the Clinician

Oana Mirela Tiucă1, Andreea Cătălina Tinca2, Sabin Turdean3, Ovidiu Simion Cotoi4, Silviu Horia Morariu5

1. Dermatology Clinic, Mures Clinical County Hospital, Targu Mures, Romania
2. Pathology Service, Mures Clinical County Hospital, Targu Mures, Romania
3. Department of Pathology, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, Romania
4. Department of Pathophysiology, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, Romania
5. Department of Dermatology, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, Romania

DOI: 10.2478/amma-2020-0026

Introduction: Non-melanocytic skin cancers represent the most frequent type of cutaneous carcinomas. Also called basosquamous cell carcinoma and considered by some authors as a clinical form of basal cell carcinoma, metatypical carcinoma represents a controversial clinical entity.
Case presentation: This paper aims to present the case of a 42-year-old female patient who presented to the doctor’s office for the appearance of a painful cutaneous tumor located in the left submandibular region. Excisional biopsy was performed. The microscopic features were consistent with the diagnosis of metatypical carcinoma with the predominance of the squamous type.
Conclusions: Taking into consideration its aggressive behavior, careful follow-up of patients diagnosed with this rare type of cutaneous tumor is mandatory for precocious identification of possible metastases and improvement of long and short term prognosis.

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Prenatal Diagnosis of Binder Phenotype, Naso-Maxillar Hypoplasia

Lucian Gheorghe Pop1, Ioan Dumitru Suciu2, Nicolae Bacalbasa3, Oana Daniela Toader1,3

1. National Institute of Mother and Child Care Alessandrescu-Rusescu, Bucharest, Romania
2. Floreasca Emergency Hospital, General Surgery Department, Bucharest, Romania
3. University of Medicine and Pharmacy-Carol Davila-, Bucharest, Romania
4. University of Medicine and Pharmacy -Carol Davila-, Bucharest, Romania

DOI: 10.2478/amma-2020-0032

Facial dysmorphism is a common diagnosis which represents a broad spectrum of aetiologies with different outcomes spreading from normal outcome to foetal demise or new-borns with multiple malformations. Prenatal diagnosis can be difficult, making counseling a challenging task even in experienced hands. This paper aims to present an unusual case of facial dysmorphism (Binder phenotype) which resulted in a normal pregnancy. However, throughout the pregnancy, future parents experienced excruciating anxiety, which required multiple prenatal counseling appointments. We believe that in case of a Binder phenotype, genetic testing, multiple scanning appointments and extensive discussion with future parents are vital in the prevention of an unneeded ending of a pregnancy.

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Pharmaceutical Serialization, a Global Effort to Combat Counterfeit Medicines

Georgiana Andreea Pascu1, Gabriel Hancu2, Aura Rusu2

1. Regulatory Affairs Department, Gedeon Richter Romania
2. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, Romania

DOI: 10.2478/amma-2020-0028

Objective: Pharmaceutical serialization is a process in the pharmaceutical industry that offers a secure solution to track and authenticate drugs in the distribution chain. The unique recognition number for every drug unit helps to identify and combat counterfeit products. This paper aims to highlight the advantages of serialization implementation as an innovative tool to combat globally the counterfeiting drugs phenomenon.
Methods: Worldwide a considerable effort was focused on enhancing medicines identification. Analytical methods, development of the new lab equipment, digital solutions, and blockchain technology are the new directions for the future. Also, legislation needs to be correlated at the international level between the pharmaceutical industry, distribution, and pharmacies.
Results: A good collaboration between responsible entities should be implemented to protect public health and to promote patients’ access to safe medicines. A directive implemented on European Union focused on fake drugs, Global Monitoring and Surveillance System launched by the World Health Organization, or the international campaign “Fight the Fakes” are remarkable examples.
Conclusions: An efficient joint effort between the pharmaceutical industry and law enforcement is required. Counterfeit medicines are a worldwide threat to public health and demand a unitary pharmaceutical serialization system to be implemented as an ideal solution.

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Clinical Evolution of Patients with Schizophrenia Associated with Addictive Disorders

Andreea Salcudean1, Melinda Ferencz2, Daniela Sabau2, Madalina Gherman3

1. Department of Medical Ethics and Socio-Human Sciences, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, Targu Mures, Romania
2. Psychiatry Clinic 1, Mureș Clinical County Hospital, Targu Mures, Romania
3. Targu Mures Emergency County Hospital, Targu Mures, Romania

DOI: 10.2478/amma-2020-0033

Introduction: The prevalence of schizophrenia in the general population is about 0.3% -0.7% Pathological use of substances such as cocaine, alcohol, amphetamines and nicotine are common in schizophrenia with a lifetime prevalence of 80%. They tend to isolate themselves in an inner world, thus being prone to substance abuse. The most commonly used substances are: alcohol, nicotine, cocaine, amphetamines, hallucinogens and cannabis.
Method: We conducted a retrospective, descriptive-analytical study on a group of 139 patients with a positive diagnosis of schizophrenia from the Psychiatry Clinic I of the Mureș County Clinical Hospital hospitalized between 01.01.2018-31.12.2019. The clinical and paraclinical data used were processed from observation sheets in the clinic archive. These were introduced and analyzed in the Microsoft Excel 2016 program, and the statistical test used was Chi Square in the Graph-Pad statistical analysis program.
Results: Most patients with schizophrenia have a schizoid (41%) and paranoid (32%) personality. Other types are: organic 25% (unstable and impulsive) and obsessive anxiety 2%. Due to the evolution of diseases, patients end up consuming psychoactive substances, tobacco and alcohol. A percentage of 48% of patients were tobacco consumers, 37% were alcohol consumers and 15% consumed psychoactive substances. Tobacco use is not a statistically significant factor in the recurrence of the disease.
Conclusions: Alcohol, tobacco and psychoactive substances are an important risk factor in the unfavorable evolution of the disease, most hospitalized patients are in the age group 50-59 years.

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Complications Following Surgery for Low Rectal Cancer – Modified Intersphincteric Resections vs Non-Sphincter Saving Technique

Vlad Olimpiu Butiurca, Andrei Modiga, Ioan Teodor Bud, Paul Cristian Russu, Marian Botoncea, Calin Molnar, Simona Gurzu

George Emil Palade University of Medicine, Pharmacy, Sciences, and Technology, Targu Mures, Romania

DOI: 10.2478/amma-2020-0031

Introduction: In patients with low rectal cancer, a proper surgical technique is aimed to confer a better quality of life following surgery and a longer time of disease-free survival. Aim: In this study, we presented the results obtained by a single surgical centre in the treatment of low rectal cancer, using two types of surgery: intersphincteric resections (ISR) and abdominoperineal resections (APR).
Material and methods: The paper was focused on the rate of complications after surgery for low rectal cancer, which was retrospectively evaluated in 132 consecutive patients who underwent surgery over a period of 5 years. The statistical comparison was done between two groups: group 1 – that underwent ISR (n=60) and group 2 – patients evaluated after APR (n=72).
Results: The quality of life, evaluated at the regular follow-up, did not show significant difference between the two groups. Clavien-Dindo grade I and above complications were registered in 9 patients (15%) from group 1 respectively 23 patients (38.33%) from the group 2.
Conclusion: ISR is a good option for surgical removal of a low rectal cancer, with a lower rate of complications, compared with APR technique.

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Effect of Caffeine on Pain Management

Paul Grama1, Miruna Pepa Oltea2, Corina Adelina Zah1

1. Faculty of Medicine, “Iuliu Hațieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania
2. Transplant and Cardiovascular Disease Institute, Targu Mures, Romania

DOI: 10.2478/amma-2020-0030

Caffeine is a widely consumed substance, as its main intake reasons are its memory and concentration enhancing properties. Beside these well-known effects, there has been put forward a hypothesis that caffeine consumption along with antinociceptive medication can potentiate the analgesic effect of this class of drugs. Our aim was to point out the importance of this particular potentiator effect by selecting and analyzing all papers on this topic written in English from the Medline database, published until the present moment. We observed that caffeine can represent a significant aid for certain patients in matters of pain management, by both reducing the pain killer doses and by increasing life quality.

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Erratum

This is a correction of the article The Statistical Analysis of Pharmacokinetic Parameters in the Context of Bioequivalence Testing of Two Anthelmintic Formulas Based on Ivermectine and Triclabendazole in Sheep (Acta Medica Marisiensis 2019;65(2):60-65. DOI: 10.2478/amma-2019-0015), published in the June 2019 issue of Acta Medica Marisiensis (currently Acta Marisiensis – Seria Medica), which contains errors in the authors’ affiliation. The correct data are presented below:

The Statistical Analysis of Pharmacokinetic
Parameters in the Context of Bioequivalence Testing of Two Anthelmintic Formulas Based on Ivermectine and Triclabendazole in Sheep

Lenard Farczadi1,2,3, Laurian Vlase2*, Orsolya Melles1, Ramona Tolomeiu4, Octavia Tamas-Krumpe4, Andreea Buta4, Laurentiu Ognean4
1. Clinical and Analytical Research Center Vim Spectrum Ltd, Sighișoarei Street, no. 409, 547367, Corunca – Mureș, Romania
2. Department of Pharmaceutical Technology and Biopharmaceutics, Faculty of Pharmacy, “Iuliu Haţieganu” University of Medicine and Pharmacy, Emil Isac street, no. 13, 400023, Cluj-Napoca, Romania
3. Center for Advanced Medical and Pharmaceutical Research of the George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, Romania
4. Department of Physiology, University of Agricultural Science and Veterinary Medicine, Mănăștur Street, no. 3-5, 400037, Cluj-Napoca, Romania

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