Category Archives: Number

Deep Venous Thrombosis Associated With Inferior Vena Cava Abnormalities And Hypoplastic Kidney In Siblings

Duicu Carmen*, Bucur Gabriela, Simu Iunius, Tripon Florin, Marginean Oana

University of Medicine and Pharmacy of Tirgu Mures, Romania

DOI: 10.1515/amma-2016-0011

Congenital inferior vena cava anomalies have a reduced frequency in general population, many times being an asymptomatic finding. Patients caring such anomalies are at risk to develop deep vein thrombosis. In this paper, we present 2 siblings with deep venous thrombosis and inferior vena cava abnormalities, with a symptomatic onset at similar age. The inferior vena cava abnormality was documented by an angio-CT in each case. The thrombophilic workup was negative. Patients were treated with conservative therapy: low molecular weight heparin anticoagulants converted later to oral anticoagulant with resolution of symptoms and disappearance of the thrombus. Finally, in the absence of any risk factor in a young patient admitted with deep vein thrombosis investigations to exclude inferior vena cava anomalies are mandatory.

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Ethical Considerations In Dental Care For People With Developmental Disabilities

Biris Carmen, Bud Eugen, Ormenian Alina, Lazar Ana Petra*, Pop Diana, Yero Eremie Lia Maria, Lazar Luminita

Universitatea de Medicina si Farmacie Tirgu Mures, Romania

DOI: 10.1515/amma-2016-0010

Developmental disabilities exist in children and adolescents, enabling them to live an independent and self-governing life, requiring special health related services. We are intended to inform dental professionals in planning and implementing a dental treatment for people with developmental disabilities. Cerebral palsy is defined as being a group of motor abnormalities and functional impairments that affect muscle coordination, and characterized by uncontrolled body movements, intellectual disabilities, balance-related abnormalities or seizure disorders. These patients can be successfully treated in normal dental practices, but because they have problems with movements, care must be tailored accordingly. Down syndrome, a very common genetic disorder, is usually associated with different physical and medical problems, intellectual disabilities, and a developmental delay. These patients can be treated with success in dental offices, this way making a difference in the medical care for people with special needs. Autism is a neurodevelopmental disorder characterized by impaired social interaction, verbal and non-verbal communication and by restricted and repetitive behavior. Self-injurious behavior, obsessive routines and unpredictable body movements can influence dental care. Because of the coexisting conditions (epilepsy or intellectual disability), one can find this people among the most challenging to treat. There is a need of greater awareness, focus and education in the field of the unique and complex oral health care that people with disabilities need. Making a difference their oral health positively influences an already challenged existence. According to the ethical principles, patients with developmental disabilities should be treated equitably depending on their necessities.

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Intracoronary Imaging for In-Stent Restenosis – Ready for Clinical Routine?

Benedek Theodora*

University of Medicine and Pharmacy Tirgu Mures, Romania

Since the first human coronary stent implantation in 1986, the number of coronary stenting procedures rapidly increased and many different types of coronary stents have been introduced in the market of cardiovascular products [1]. Despite the introduction of new generation stents with superior quality (drug eluting or bioabsorbable stents) and despite the increasing experience in performing stenting procedures, the restenosis within the implanted stent, known as in-stent restenosis (ISR), continues to represent a major healthcare problem. ISR was noted in approximately 30% of cases following implantation of bare metal stents, however its incidence significantly decreased after introduction of new drug eluting stents (DES) in the recent years. [More]

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Bulk Fill Resin Composite Materials Cured with Single-Peak versus Dual-Peak LED LCUs

Aldossary Mohammed1,2, Roebuck Elizabeth M1, Santini Ario3*

1 Department of Paediatric Dentistry. The University of Edinburgh, Edinburgh Dental Institute, Lauriston Place, Edinburgh EH3 9HA, United Kingdom
2 King Salman Hospital, Ministry of Health, Riyadh, Kingdom of Saudi Arabia
3 The University of Medicine & Pharmacy, Tg-Mures, Romania

DOI: 10.1515/amma-2016-0009

Introduction: Manufactures claim that recently introduced bulk fill materials (BFM) can be cured adequately in 4 mm increments. This requires adequate light energy to be transmitted through the material to ensure adequate polymerization at the bottom of the increment.
Aim: To compare the total light energy transmission through three BFMs and bottom/top (B/T) surface Vickers hardness (VH) when cured with single-peak versus dual-peak LED LCUs.
Methods and Materials: Samples (n=5) of two viscous BFMs, Tetric EvoCeram® Bulk Fill X-tra fil® [XF] flowable SureFil, were prepared. A conventional RBC, Tetric EvoCeram® was used as a control. Using MARC® RC, the irradiance delivered to top surface of samples was adjusted to 1200 mW/cm2. Samples were cured with singlepeak EliparTM S10 or dual-peakBluephase® G2 for 10 seconds and irradiance transmitted to the bottom surface measured. Samples were stored for 24 hours, prior to VH measurements B/T VH ratios were calculated.
Statistically analysed used oneway ANOVA (α=0.05).
Results: There was no statistically significant difference for B/T total energy transmission between materials except XF with EliparTM S10 (P<0.001). Total energy transmission ranged from 0.7 J/cm2 to 1.5 J/cm2. There was no statistically significant difference for B/T VH ratios between materials (P>0.05) when materials were cured with single-peak versus dual-peak LCU’s, XF>SDR>TEC>TBF. TBF alone, did not reach the generally accepted B/T VH of 80%.
Conclusions: Both single-peak and dual-peak LCU’s were equally effective for curing the studied bulk fill materials. Manufacture’s recommended total energy delivered to the top surface may not always be sufficient for effective curing.

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Role of Transurethral Resection of the Prostate in the Management of Prostate Cancer

Szollosi Attila, Martha Orsolya, Denes Lorand, Vida Arpad Oliver, Maier Adrian, Pavai Zoltan

University of Medicine and Pharmacy Tirgu Mures, Romania

DOI: 10.1515/amma-2016-0008

Introduction: Prostate cancer is the second most diagnosed cancer in men, after lung cancer. The gold standard procedure in prostate cancer (PCa) diagnosis is the ultrasound guided prostate biopsy. Transurethral resection of the prostate (TURP) used in solving the bladder outlet obstruction, can have a role in detection of PCa. The aim of this retrospective study is to examine the role of transurethral resection of the prostate in the diagnosis and therapy of prostate cancer.
Materials and methods: At the Urology Clinic of Targu Mures we performed a total of 474 TURP over a two year period (2011-2013). The patients had a mean age of 71.857 years, and the indications were PCa with bladder outlet obstruction or bladder outlet obstruction with unknown causes but some with suspicion of PCa.
Results: In case of 474 patients with TURP performed for bladder outlet obstruction, the histopathology findings were the following: 61 cases with newly diagnosed PCa, some in spite of normal PSA values, 23 cases with already hormone treated prostate cancer, while in 50 cases TURP was preceded by prostate biopsy (in 8 cases with increased PSA and several negative biopsies, we could confirm PCa of the peripheral zone of the prostate).
Conclusion: TURP remains the elective surgical therapy of the bladder outlet obstruction, caused by BPH and even prostate cancer. Obtaining a greater volume of prostate tissue can help in the detection of prostate cancer in its early stages, especially in the transitional zone.

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The Effectiveness of Using Medical Students for Training High School Students in Cardiopulmonary Resuscitation

Dîrzu Dan Sebastian1,2*, Hagău Natalia1, Boț Theodor3, Fărcaș Loredana3, Copotoiu Sanda Maria4

1 Department of Anesthesia and Intensive Care, University of Medicine and Pharmacy ”Iuliu Hațieganu”, Cluj Napoca
2 University of Medicine and Pharmacy Târgu Mureș,
3 University of Medicine and Pharmacy ”Iuliu Hațieganu”, Cluj Napoca,
4 Department of Anesthesia and Intensive Care, University of Medicine and Pharmacy Târgu Mureș

DOI: 10.1515/amma-2016-0005

Introduction: Training for cardiopulmonary resuscitation is a very important topic for society, trainers and researchers. However it is not yet established who should be trained and by whom nor how the training programmes should be accomplished. We developed a study to evaluate an existing programme where medical students train high school students in cardiopulmonary resuscitation using instrumented mannequins to teach and collect performance data.
Method: The students of four randomly selected high school classes were trained by four randomly selected medical students and were evaluated by an independent evaluator. The level of knowledge provided and the level of technical skills acquired were analysed.
Results: One hour of lecturing was enough to increase the mean of correct answers from 39.52% to 78.48% when we tested knowledge. Testing for skills retention we found that that 92.75% of trained students taped the shoulder; 95.65% asked loudly “Are you all right?” at the right moment; 97.1% shouted for help at the right moment, the entire group remembered to check the breathing at the right moment, and 92.75% executed a correct head tilt chin lift manoeuvre; 86.9% remembered to call 112 at the right moment. Automatic recordings showed that mean flow fraction was 80.74%, mean no flow time was 18.9 seconds, mean frequency of chest compressions was 134.7/min and mean compression depth was 39.06 mm.
Conclusions: The results showed that high school students achieved a good level of knowledge and acceptable cardiopulmonary resuscitation skills when trained by medical students.

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Determination of HMG-CoA reductase inhibitors by micellar electrokinetic chromatography

Eleonora Mircia, Gabriel Hancu*, Aura Rusu, Adriana Cazacu, Teodora Balaci, Ruxandra Soare

University of Medicine and Pharmacy Tirgu Mures, Romania

DOI: 10.1515/amma-2016-0006

Objective: In this study we report the development of a simple, rapid and efficient capillary electrophoresis method for the simultaneous determination of atorvastatin, fluvastatin, lovastatin and simvastin.
Methods: Capillary zone electrophoresis proved to be efficient for the simultaneous separation of atorvastatin and fluvastatin, but could not resolve the determination of lovastatin and simvastatin. The simultaneous separation of all four statins was achieved by applying a micellar electrokinetic chromatographic method, after transforming lovastatin and simvastatin in β-hydroxyl acid forms through alkaline hydrolysis. The optimum electrophoretic conditions and analytical parameters were investigated and the analytical performances of the method were verified with regard to linearity, precision, accuracy, LOD and LOQ.
Results: The optimum electrophoretic separation conditions were: 25 mM sodium tetraborate with 25 mM sodium dodecyl sulphate buffer electrolyte at pH 9.5, applied voltage + 25 kV, separation temperature 25 °C, injection pressure/time 50 mbar/1 minutes, UV detection at 230 nm. Using the optimized electrophoretic conditions we succeeded in the simultaneous determination of the four statins in approximately 3 minutes, the order of migration being: atorvastatin, fluvastatin, lovastatin, simvastatin. The proposed method has been applied to the determination of the analytes in pharmaceutical tablets formulations.
Conclusions: The capillary electrophoretic method developed in the present work proved to be suitable for the routine analysis of statins and can be adopted as quality control protocol in pharmaceutical analysis.

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